API & Excipients for Pharmaceutical

API & Excipients for Pharmaceutical

In API portfolio, Sigachi primarily offers below 9 API Products and their Intermediates meeting all regulatory requirements. Sigachi strictly complies to all the regulatory standards and cater to Domestic & International Markets at an affordable rate with the best quality. Sigachi offers below API’s –

S.No	Product	CAS	Ph Ref	Therapeutic Category
1	Pregabalin	148553-50-8	USP	Pregabalin is an anticonvulsant drug used to treat neuropathic pain conditions and fibromyalgia, and for the treatment of partial onset seizures in combination with other anticonvulsants.
2	Ritonavir	155213-67-5	USP	Ritonavir is a protease inhibitor used for the treatment of HIV/AIDS.
3	Metformin Hcl	1115-70-4	USP	Metformin is an oral anti-diabetic drug in the biguanide class for the treatment of type 2 diabetes mellitus, in particular, in overweight and obese people and those with normal kidney function
4	Propafenone Hcl	34183-22-7	USP	Propafenone is a Class 1C antiarrhythmic drug with local anesthetic effects, and a direct stabilizing action on myocardial membranes. It is used in the treatment of atrial and ventricular arrhythmias.
5	Atorvastatin Calcium trihydrate	344423-98-9	USP	Atorvastatin, is a lipid-lowering drug included in the statin class of medications. By inhibiting the endogenous production of cholesterol in the liver, statins lower abnormal cholesterol and lipid levels, and ultimately reduce the risk of cardiovascular disease.
6	Nimorazole	6506-37-2	IH	Nimorazole has been used in trials studying the treatment of Hypoxia, Radiotherapy, Hypoxic Modification, Gene Profile, Gene Signature, and Head and Neck Squamous Cell Carcinoma, among others.
7	Naftopidil	57149-07-2	IH	Naftopidil is a peripheral α1-adrenergic receptor antagonist used to treat lower urinary tract symptoms (used in the treatment of benign prostatic hyperplasia.)
8	Meclizine HCl	1432062-16-2	USP	Meclizine belongs to a drug class called antihistamines, which are often used to treat allergies
9	Minoxidil	38304-91-5	USP	Minoxidil is used to stimulate hair growth and to slow balding. It belongs to the general class of medicines called antihypertensives. It is used to treat high blood pressure (hypertension)

BARETab® PH

Pre-formulated co-processed excipient for continuous manufacture of pharmaceutical tablets.

Characteristics:

• Superior flowability
• Enhanced compactability
• Increased drug loading
• Batch uniformity

BARETab® ODT

Pre-formulated co-processed excipient for orally disintegrating tablets.

Characteristics:

• Greater hardness
• Decreased disintegration time
• Lesser friability
• Good mouth feel

HiCel^TM HFS

Co-processed excipient for oral and sub-lingual formulations.

Characteristics:

• Lesser lubrication sensitivity
• Enhanced flowability
• Faster disintegration

HiCel^TM CE15

Have a good mouth feel with HiCel CE15 in your chewable formulations.

Characteristics:

• Good mouth feel
• Enhanced organoleptic features
• Low friability
• Rapid disintegration

HiCel^TM MCG

Increase your product stability with HiCelTM MCG in your formulation.

Characteristics:

• Stable over wide pH range
• Good suspension stability
• Content uniformity

HiCel^TM SMCC

Increase the pysico mechanical strength of your formulations with HiCelTM SMCC.

Characteristics:

• Finer particle distribution
• Optimal compaction
• Superior flow

Stargel®

Sodium starch glycolyte (SSG) as Stargel is available as Type A, Type B and Type C suitable for tablet and capsule formulations.

Characteristics:

• Strong swelling properties
• Effective even in non soluble matrices
• Effective in direct compression & granulation techniques as well

HiLose^TM

Cross Carmellose Sodium (CCS) as HiLoseTM in formulations is efficient at low level of use and cross linking allows enhanced bioavailability of the drug through superior drug dissolution.

Characteristics:

• Outstanding water wicking capability generates the volume expansion
• Robust tablets while maximizing production speed
• Enhanced stability and greater batch to batch consistency
• High porosity results in uniform and consistent loading of API

HiCel^TM

The HiCelTM brand of Microcrystalline Cellulose is by far the most consistent brand in the Cellulose industry. HiCelTM is spray dried directly compressible form of MCC . HiCelTM is available in several grades which varies in their average particle size moisture content and bulk density

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